产品货号：
Z10106
中文名称：
53BP2/TP53BP2抗体
英文名称：
Anti-53BP2/TP53BP2 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-53BP2/TP53BP2 Antibody |
| 指标别名 | 53BP2;ASPP2;BBP;p53 binding protein 2;p53BP2;PPP1R13A;TP53BP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | TP53BP2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human ASPP2. |
| 计算分子量 | 126kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This Protein A purified antibody is directed against human ASPP2.The product was purified from monospecific antiserum by Protein A affinity chromatography.Minimal reactivity occurs against ASPP1.A BLAST analysis was used to suggest cross-reactivity with ASPP2 from macaque and dog sources based on a 100% homology with the immunizing sequence.?Expect partial reactivity with ASPP2 from mouse and rat sources based on an 80% homology with the immunizing sequence.?Reactivity against homologues from other sources is not known. |
| 浓度 | 2.4mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | ASPP (ankyrin-repeat-,SH3-domain- proline-rich-region protein) proteins (ASPP1,ASPP2 and iASPP) represent a new family of p53 binding proteins.ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.In contrast,iASPP functionally inactivates p53.ASPPs may also regulate p63- and p73-mediated apoptosis.Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes,such as Bax and PIG-3.Not all cell cycle arrest genes are affected,such as p21.?Interestingly,expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.Therefore,ASPP might regulate the tumor suppression function of p53 in vivo. |
| Uniprot ID | Q13625 |
| 基因名全称 | Apoptosis-stimulating of p53 protein 2 |
| 推荐稀释比 | ELISA:1:2,500 - 1:10,000 IHC:User Optimized WB:1:500 - 1:3,000 |
相关搜索：53BP2/TP53BP2抗体，53BP2抗体，TP53BP2多抗，Anti-53BP2/TP53BP2 Antibody